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It likely reflects individual differences in receptor sensitivity, gut microbiome composition, genetics, and the complex interplay of hormonal systems that regulate body weight
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Ketamine effects on intracellular signaling to mediate antidepressant action Earlier studies on the mechanisms of action of classical antidepressant in preclinical models established a strong causal link of BDNF and subsequent signaling via TrkB receptors as a key mediator of antidepressant action [99, 100]
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