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Several mechanisms lead to insulin resistance in OSA, including hypoxia, sleep fragmentation, sympathetic nervous system activation, dyslipidemia, oxidative stress, and inflammation [45,46,47]
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Here's the comparison that ought to give the field pause: disulfiram and acamprosate, the actual approved AUD drugs, showed an adjusted hazard ratio of 0.98 in that same analysis, essentially no reduction in hospitalization risk
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