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Liraglutide (Figure 1D), dulaglutide (Figure 1E), semaglutide (Figure 1F), and tirzepatide (Figure 1H), which incorporate fatty acid conjugation using a linker or an IgG fragment crystallizable (Fc) region, display minimal renal clearance and prolonged half-lives (Figure 2C–G).60 Detailed information on their pharmacokinetic characteristics is provided below