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The reductions noted in this trial, the team noted, were “associated with long-term reductions in alcohol-related negative consequences, improvement in mental health, and aligns with improvement in self-evaluated general and psychological health in the semaglutide group” in the trial, “although these improvements were modest.” The most common adverse effects reported were gastrointestinal, and were more frequent in the semaglutide group, but most were short-lived, and none were severe

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Unlike oral semaglutide, which must be taken fasting with limited water, orforglipron can be taken at any time of day without food or water restrictions