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For example, recent studies have reported clinical benefits in patients with heart and kidney failure

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72 Although we previously observed that systemic GLP-1 infusion at pharmacological concentrations increases both muscle microvascular perfusion and glucose use in rats, 69 intra-arterial infusion of GLP-1 at physiological concentrations, in the presence or absence of octreotide infusion to block endogenous insulin infusion, increased muscle microvascular perfusion without increase glucose uptake in humans