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(2013) Transcriptional regulatory factor X6 (RFX6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity
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For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]
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