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Published data demonstrate that when type 2 diabetics are put on the a dietary program that was consistent with the Zone diet in both the levels of calorie restriction (1,200 to 1,500 calories per day) and a macronutrient composition (40% carbohydrates, 30% protein, and 30% fat) the result was not only is there complete remission of their diabetes, but also an increase in their lean body mass (7)

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The lack of a denominator for the total population taking the medications, where reports came from European and non-European countries, makes it difficult to determine if there is a significant risk