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Ex4 was the first GLP-1R agonist found to attenuate alcohol's rewarding properties in male mice, as systemic administration of Ex4 blocked the alcohol-induced dopamine release in NAc (8), locomotor stimulation (8), and reward in the conditioned place preference test (8, 9)

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Signs of Melatonin Overdose Common side effects of melatonin overdoses include: Daytime grogginess Headaches Depression Anxiety Diarrhea Stomach cramps Irritability Joint pain Dizziness Low body temperature Taking too much melatonin can have a wide range of harmful effects