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Vagal signaling can be traced to the parvicellular reticular nucleus (PCRt) 86 , a region receiving GABAergic projections in the central amygdala (CeA), involved in the state-dependent modulation of locomotion, especially feeding- and appetitive-related locomotion 87
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Answer: As of April 2026, 9 mg and 12 mg weekly are the doses with confirmed Phase 3 efficacy data, both from the TRIUMPH-4 readout (26.4 percent and 28.7 percent mean weight reduction at 68 weeks, respectively)
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