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The titration schedule for Ozempic —starting at 0.25 mg once weekly and gradually increasing to maintenance doses of 0.5 mg, 1 mg, or 2 mg—is designed to minimise gastrointestinal side effects, but individual tolerance varies considerably

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9-13 A key unanswered question is whether GLP-1 agonists, beyond promoting weight loss, can directly target chronic synovial inflammation

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