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Patients were randomized 1:1 to receive subcutaneous semaglutide 2.4 mg once weekly or placebo as an adjunct to standard-of-care therapy for CVD, such as cholesterol-modifying medications, antiplatelet therapies and antihypertensive agents
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The NF-kB connection GLP-1 receptor activation, whether by natural GLP-1 or pharmaceutical agonists, inhibits the nuclear factor kappa-B (NF-kB) inflammatory pathway
