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In the intracellular side, a sharp kink located in the conserved Pro 6.47b -X-X-Gly 6.50b motif pivoted the intracellular tip of TM6 to move outwards by 19.3 Å (measured by Cα atom of K344 6.35b ), slightly higher than that seen with the GCG–GCGR–G s (17.7 Å) 4
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