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The Th17 marker gene Rorγt and the Th1 and Th2 regulatory genes Tbet and Gata3 were also significantly elevated, accompanied by a significant increase in various systemic inflammation-related genes such as interferon gamma ( IFN-γ ), etc ( In vitro experiments showed that liraglutide could reduce the proliferation activity of CD4 + IFN-γ + T cells (Th1) and CD4 + IL-17a + T cells (Th17), but increase the number of CD4 + IL-4 + T cells (Th2) and CD4 + CD25 + T cells (Treg)