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Biologic therapies effectively target specific inflammatory mediators, but do not directly address metabolic dysfunction or oxidative stress, both of which contribute to HS severity
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Post hoc evaluations of the SUSTAIN 6 trial revealed that semaglutide markedly increased the incidence of diabetic retinopathy complications in individuals with a history of retinopathy, especially among insulin users, presumably due to the swift deterioration of pre-existing retinopathy following rapid glycemic control [91]
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