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Key Clinical Implications ✔ First evidence linking GLP-1RA use to lower obesity-associated cancer incidence specifically in obese, nondiabetic patients ✔ Potential dual benefit for weight management and cancer risk reduction ✔ Racial disparities in treatment response warrant further investigation and may impact prescribing decisions ✔ Findings support existing trends toward expanded GLP-1RA use for obesity management beyond diabetes Bottom Line This large retrospective study provides the first evidence that GLP-1 receptor agonists may be associated with reduced cancer risk in obese adults without diabetes