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Substance-use screening is handled directly: an opt-out exclusionary block flags current alcohol, opioid, or substance-use disorder, and a separate three-month opiate-history field requires free-text date range, name, dose, and frequency before the patient can advance

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Refrigeration at the recommended temperature (36°F to 46°F or 2°C to 8°C) is crucial, and users should be cautious about prolonged exposure to room temperature or excessive heat