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The previously published 44 ChIP-seq dataset data re-used in this study are available in the Gene Expression Omnibus database under accession code GSE159648

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Key results The results were dose-dependent and remarkable at every level: 1mg: Approximately 8.7% weight loss 4mg: Approximately 17.1% weight loss 8mg: Approximately 22.8% weight loss 12mg: Approximately 24.2% weight loss Placebo: Approximately 2.1% weight loss The 24.2% weight loss at 12mg over 48 weeks was unprecedented