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A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain
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GIP (secreted by enteroendocrine K cells, which are predominantly located in the duodenum) and GLP-1 (secreted by enteroendocrine L cells, which are located in the distal gut) are rapidly degraded by the ubiquitous enzyme dipeptidyl peptidase-4 (DPP-4) [1,2,74]
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