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Conclusion: Cinchonine, a potential oral small-molecule GLP-1R agonist, could reduce blood glucose and ameliorate NASH, providing a strategy for developing small-molecule GLP-1R agonists

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In a follow-up study, a calorie-restricted weight-matched group was introduced alongside the vehicle, GLP-1, MK-801 and GLP-1–MK-801 groups (Extended Data Fig