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Individual Side Effects: What to Expect and How Community Sources Manage Each Nausea Frequency: 27% of trial participants Onset: 1-4 hours post-injection Duration: 4-8 hours typically Severity: Dose-dependent, most severe weeks 1-6 Nausea is the hallmark side effect of retatrutide, though it occurs less frequently than with high-dose tirzepatide (up to 45% at 15 mg)

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