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Additionally, weight loss from semaglutide can change metabolic demands, potentially requiring levothyroxine dose adjustments over time

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Furthermore, GLP-1R/glucagon receptor dual agonists are being investigated for the treatment of NAFLD ( The pathogenesis of non-alcoholic fatty liver disease The first phase of NAFLD is characterized by accumulation of fat in the liver (hepatic steatosis), which may progressively lead to NASH (in 5–20% of patients) with or without concomitant fibrosis