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29 GIP Agonism as a Potential Therapeutic Approach for Atherosclerotic Cardiovascular Disease The cardioprotective actions of incretin-based agents, particularly the GLP-1RAs, have a bulk of supporting evidence in the form of clinical studies

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both agencies continue to investigate this safety signal." [26] Suicidal behavior and ideation [edit] In January 2026, the US Food and Drug Administration requested removal of suicidal behavior and ideation warning from glucagon-like peptide-1 receptor agonist (GLP-1 RA) medications