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Specifically, participants with hyperphagic depression showed a positive association between postprandial change in ghrelin levels and anticipatory food reward responses in the VTA and left hypothalamus, while participants with hypophagic depression showed a negative association in the right hypothalamus (Cerit et al., 2019)
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Setmelanotide, a melanocortin-4 receptor agonist used for rare genetic obesity disorders, has limited clinical experience in patients with hepatic impairment
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