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In contrast, insoluble fibers such as wheat bran primarily increase fecal bulk through mechanical distension but show variable efficacy and can exacerbate bloating or discomfort in IBS-C or methane-positive phenotypes ( From a translational perspective, the efficacy of fiber depends on fermentability, solubility, and adaptation of the microbiota
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Antimicrob Agents Chemother 1989;33:1841-4
