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In rats, feeding activity and food intake decreased following intracerebroventricular injection of GLP-1, an effect counteracted by co-administration of a GLP-1 receptor antagonist (71, 72), suggesting central GLP-1 as a potent inhibitor of feeding

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Accordingly, this section summarizes GLP-1RA and DPP-4is related mechanisms, with a focus on DPP-4is/GLP-1-mediated central effects ( Figure 2 ), to support the biological plausibility of the proposed “DPP-4is-gut microbiota-SCFAs-GLP-1 axis.” Figure 2 4.1 Enhancement of inhibitory synaptic transmission γ -aminobutyric acid (GABA)-mediated inhibitory synaptic transmission plays a critical role in regulating the excitability of neural circuits and controlling epileptic seizures