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Frontiers | The Impact of Glucagon-Like Peptide 1 Receptor Agonists on Bone Metabolism and Its Possible Mechanisms in Osteoporosis Treatment
The combination results in three convergent signals: reduced caloric intake (GLP-1/GIP appetite suppression), improved insulin sensitivity (GIP/GLP-1 pancreatic effects), and elevated calorie burn (glucagon thermogenesis)
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Rather, it is to engineer a pharmacologic signal in which glucagon’s catabolic properties are preserved while its hyperglycemic liability is buffered by incretin-mediated glucose control
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