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2 GLP-1RAs as Favorable Factors for Myelin Formation and Maintenance 2.1 ALS Models There is increasing evidence that impaired GLP-1 signaling is associated with the progression of ALS ( 2.2 Wolfram Syndrome Model Wolfram syndrome (WS) is an autosomal recessive neurodegenerative disorder characterized by childhood-onset diabetes mellitus and various neurological manifestations, including progressive optic nerve atrophy, sensorineural hearing loss and cognitive impairment ( 2.3 Nerve Injury Models 2.4 Diabetic Neuropathy Models There is enough evidence that the main pathology of diabetic neuropathy is axonal degeneration, which precedes demyelination observed in patients with the disease at advanced stages ( 2.5 Neuron–Schwann Cell Co-Culture Models Co-culture systems of neurons and Schwann cells have enabled us to generate myelin structures nearly equivalent to those in living bodies, thereby being recognized as useful tools to investigate neuron-Schwann cell interactions (Figure 1A)
