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If you treat migraines with oral triptans (sumatriptan, rizatriptan) and notice they work more slowly on semaglutide, consider: Switching to a triptan nasal spray or subcutaneous injection (bypasses gastric absorption) Taking the triptan at the first sign of aura or prodrome, not waiting for pain Discussing preventive migraine medications with your provider if abortive treatment becomes unreliable Antibiotics for acute severe infection