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Meanwhile, the SURMOUNT-4 trial showed that withdrawing tirzepatide and switching to placebo led to substantial 14.0% regain of lost weight, whereas continued tirzepatide therapy maintained and even slightly augmented the initial 5.5% weight reduction [37]

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Following the success of these single-center exenatide PD clinical trials, Foltynie and colleagues have initiated a multi-center, phase 3 clinical trial to evaluate once weekly extended-release exenatide (Bydureon ® ) over a 96-week period to define whether exenatide’s advantageous actions are symptomatic or disease-modifying to potentially impact disease progression, or combined elements of both (Exenatide-PD3