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The buffer is a phosphate buffer: Disodium phosphate dihydrate (Na₂HPO₄·2H₂O) acts as the conjugate base Hydrochloric acid or sodium hydroxide fine-tunes the ratio during manufacturing Phosphate buffers are preferred over citrate or acetate buffers for subcutaneous peptide injections because phosphate has minimal tissue irritation and a pKa (7.2) close to the target pH
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