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Retatrutide (Triple GLP-1 + GIP + Glucagon Agonist) Retatrutide (LY3437943) is described in clinical literature as a triple hormone-receptor agonist targeting: GIPR GLP-1R Glucagon receptor (GCGR) (New England Journal of Medicine) Why adding glucagon receptor activity is scientifically interesting and important Glucagon receptor signalling is associated with: increased energy expenditure pathways hepatic metabolic effects potentially different body-composition dynamics compared to GLP-1–only approaches Glucagon receptivity means that muscle may be stimulated through increased glucose utilisation in muscle cells

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Patients suffering from IBD often display metabolic changes concomitantly to altered adipokine levels and increased inflammatory parameters (157–160)