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Hyperinsulinemia and ectopic lipid accumulation promote activation of pro-inflammatory pathways, including Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling and NLRP3 inflammasome activation, which in turn exacerbate loss of immune tolerance [52,53]
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Those patches, which are not FDA approved, don’t contain GLP-1 medications but are often marketed around weight loss
