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Once activated by increases in AMP:ATP and ADP:ATP ratios (indicative of cellular energy balance being compromised), AMPK acts to restore energy homeostasis by switching on catabolic pathways generating ATP, while switching off cellular processes consuming ATP (Fig
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FIGURE 6 5 Conclusion This work not only provides the molecular pharmacological basis for LEO’s anti-diabetic efficacy but more innovatively identifies MPC2 as a pivotal therapeutic target bridging gut microbial metabolism with enteroendocrine hormone secretion
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