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Eli Lilly states that orforglipron 12 mg and 36 mg outperform oral semaglutide 7 mg and 14 mg on the primary endpoint (HbA1c reduction at 52 weeks) and all key secondary endpoints, including weight loss and achievement of lower glycemic targets, and emphasizes that orforglipron can be taken without food or water‑timing restrictions, positioning it as a convenient, high‑efficacy oral GLP‑1 option for patients and clinicians
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